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Their behavior in animal (salamander) cells was described by Walther Flemming, the discoverer of mitosis, in 1882.

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In some cases there is even significant variation within species.

Although the replication and transcription of DNA is highly standardized in eukaryotes, the same cannot be said for their karyotypes, which are highly variable.

There is variation between species in chromosome number, and in detailed organization, despite their construction from the same macromolecules.

and for a test that detects this complement or measures the number.

Karyotypes describe the chromosome count of an organism and what these chromosomes look like under a light microscope.

For humans, white blood cells are used most frequently because they are easily induced to divide and grow in tissue culture.

Sometimes observations may be made on non-dividing (interphase) cells.But when they obtained a couple more specimens they confirmed [their findings].The number of chromosomes in the karyotype between (relatively) unrelated species is hugely variable.It is New Latin from Ancient Greek κάρυον karyon, "kernel", "seed", or "nucleus", and τύπος typos, "general form").The next stage took place after the development of genetics in the early 20th century, when it was appreciated that chromosomes (that can be observed by karyotype) were the carrier of genes.Normal karyotypes for females contain two X chromosomes and are denoted 46, XX; males have both an X and a Y chromosome denoted 46, XY.

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